What it means
A transaction that reverts with the raw data 0xcd21db4f hit the custom error SignatureExpired, defined in Uniswap Permit2. The explorer shows the hex because it does not have the contract's ABI to translate it.
The signed permit had a deadline and the transaction missed it, usually because it sat unmined too long.
How to fix it
Rebuild and re-sign the trade with a fresh quote so the new deadline is in the future, and use a market-rate fee so it mines in time.